iTunes U is a piece of software created by Apple that may be used by colleges and universities to distribute digital lessons and other files to their students. Professors may choose to upload podcasts and other media files through the iTunes U plugin on Blackboard, and students may then access those files in the same way they buy music through the iTunes store.
Click on the link below for step-by-step instructions on how to set up a course on iTunes U:

Still have questions? Take a look at the Apple website’s documentation and tutorials:
Link to Apple’s iTunes U Support